Tag Archives: lake pollution

GWAS Yields SNPs Linked to Arsenic Metabolism, Toxicity in Bangladesh

Save The Water Arsenic Poisoning Post 19

Posting
Vol. 1 Post 19
By a GenomeWeb
staff reporter
February 24, 2012

save the water, “save the water”, “non profit”, haiti, “ horizon oil spill”, “dirty water”, BPA,“contaminated water”, “water research”, “water”, “clean water”, “safe water”, “drinking water”, “water treatment”, “water testing”, “water analysis”, “bacteria”, “fluoride”, “pesticides”, “herbicides”, “organic chemicals”, “arsenic”, “ inorganic chemicals”, “bottled water”, “tap water”
 
 
 
 
 
  
 
 
 
 
 

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save the water, “save the water”, “non profit”, haiti, “ horizon oil spill”, “dirty water”, BPA,“contaminated water”, “water research”, “water”, “clean water”, “safe water”, “drinking water”, “water treatment”, “water testing”, “water analysis”, “bacteria”, “fluoride”, “pesticides”, “herbicides”, “organic chemicals”, “arsenic”, “ inorganic chemicals”, “bottled water”, “tap water”

 

Save the Water Arsenic Poison Bangledash
By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – Genetic variants influencing the expression of an arsenic-methylating enzyme contribute to inter-individual variation in arsenic metabolism and toxicity, according to a study appearing online last night in PLoS Genetics.

A research team from the US and Bangladesh tracked down a handful of chromosome 10 variants with ties to arsenic metabolism through a genome-wide association study involving more than 1,300 individuals from Bangladesh who had been exposed to arsenic through contaminated drinking water. When they tested thousands more individuals, the investigators found that some of the same variants linked to levels of arsenic metabolites in urine were also associated with the presence of an arsenic-related skin condition.

Moreover, they reported, at least some of the SNPs in this region appear to influence the expression of nearby chromosome 10 genes, including one called AS3MT that codes for the arsenite methyltransferase enzyme.

“We identified multiple genetic variants in the 10q24.32 region near AS3MT … that show robust associations with urinary concentrations of arsenic metabolites, risk for arsenical skin lesions, and local gene expression, including transcript levels of AS3MT,” University of Chicago human genetics researcher Habibul Ahsan, the study’s senior author, and colleagues wrote.

Millions of Bangladeshis have been exposed to arsenic since the 1970s, when wells were installed to tap groundwater sources that contained higher than anticipated levels of the naturally occurring chemical. Drinking water-related exposure to arsenic has occurred in other parts of the world as well, the researchers explained, including parts of the US.

Not much is known about the genetic factors mediating arsenic metabolism or toxicity during chronic arsenic exposure, though there seems to be a good deal of variability from one individual to the next.

“Whatever the source of exposure, different individuals vary with respect to their susceptibility to the toxicity of arsenic,” Ahsan said in a statement. “Even if they consume or are exposed to arsenic at the same dose and duration, some individuals will manifest toxicity phenotypes and others won’t.”

To explore the genetic basis of these differences, the team used Illumina arrays to genotype 1,313 arsenic-exposed individuals from Bangladesh.

They then looked for genetic patterns corresponding to participant’s urine concentrations of inorganic arsenic and of two arsenic metabolites: monomethylarsonic acid, a metabolite produced through methylation of inorganic arsenic, and dimethylarsinic acid, a less toxic and more easily excreted compound formed at later stages of arsenic metabolism.

The search led to several SNPs in a chromosome 10 region that showed ties to either urine MMA concentrations, urine DMA concentrations, or to the ratio of these two metabolites in urine.

At least a subset of these arsenic metabolism-associated variants also influences arsenic toxicity, researchers reported, specifically the development of a pre-malignant skin condition attributed to arsenic exposure.

When the team tested 1,085 affected individuals and 1,794 arsenic-exposed but unaffected controls, it found that the variants influenced skin lesion risk — a pattern that held in analyses involving hundreds of individuals for whom prospective arsenic exposure information was available.

In an analysis that brought together SNP and gene expression information for 950 participants, meanwhile, researchers found that some of the arsenic toxicity-associated variants on chromosome 10 appear to have regulatory effects on the nearby genes C10otf32 and AS3MT, which code for the arsenite methyltransferase enzyme.

Together, results of the study support the notion that those who are able to most efficiently metabolize arsenic via methylation are at reduced risk of toxicity.

Based on these findings, members of the research team have speculated that therapeutics that boost methylation might curb some of the toxic effects of arsenic in those who are prone to poorer arsenic metabolism.

“Now that we understand the molecular basis of some of this disease risk, it is conceivable to now think of incorporating this information into testing, evaluating, or potentially coming up with successful biomedical interventions,” Ahsan said in a statement.

“By exploiting these metabolic pathways for a subgroup of individuals who will really be at higher risk for getting those diseases,” he added, “we may be able to reduce fatal outcomes in this population.”

 

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Pennsyvlania Groups Warn of Nuclear Plant Dangers to Drinking Water

Save The Water Pennsyvlania Groups Warn of Nuclear Plant Dangers to Drinking WaterSave the WaterTM WaterArchive Posted 03/03/2012

Originally Posted on January 30, 2012 by Cynthia

Nuclear plants in the U.S. and abroad are putting drinking water sources at risk, two Pennsylvania environmental groups claim. The groups pointed to the a continuing nuclear crisis in Japan that originated with last year’s catastrophic tsunami as an example of a nuclear power plant that impacted drinking water supplies thousands of miles away.

The Pennsylvania Public Interest Research Group Education Fund and PennEnvironment Research & Policy Centerwarned that nuclear power poses potential dangers to drinking water in a study the nonprofits released. The groups stated that 49 million Americans are drinking water that originates from within 50 miles of a nuclear power plant, according to The Times Leader.

As we’ve written, the Fukushima Daiichi plant, built by General Electric, was damaged by the massive earthquake and tsunami that hit Japan last March 11. The failure of the venting system allowed hydrogen explosions to occur, which, in turn, sent large amounts of radioactive materials into the air. While use of the venting system still would have allowed radiation to escape into the atmosphere, it would have been much less than what was released in the explosions.

Concerns about radiation from Japan prompted the U.S. Food & Drug Administration (FDA) to halt the import of produce and dairy products from areas of Japan near the damaged reactors, and to screen seafood and other products imported from that country. The Environmental Protection Agency (EPA) also stepped up monitoring of radiation in air and water in the U.S. Most recently, we wrote that radioactive material believed to be from the stricken Fukushima Daiichi nuclear power plant was found in Japanese baby formula.

The Times Leader noted that the reactor released hundreds of times the legal limit of radioactive isotopes into the sea, forcing the Japanese government to order residents living within 12.4 miles of the plant to evacuate, and urging those within 18.6 miles to leave, as well. The U.S. government encouraged its residents living within 50 miles to evacuate.

A study found that drinking water sources from as far as 130 miles away were contaminated with radioactive iodine and believe that the drinking water supplied to thousands of Americans could be in danger; some already may have been impacted by releases of tritium, a radioactive form of hydrogen, said The Times Leader. Tritium can cause cancer and increase birth defect rates when consumed regularly, said The Associated Press (AP) which noted that, in the U.S., the toxin has leaked from no less than 48 of 65 American nuclear sites examined.

The study also revealed that 59 American nuclear power plants are located within 50 miles of a reservoir or other site where surface water is taken for consumption and study authors conclude that nuclear power risks in the U.S. should force the federal government to retire existing plants no later than at the end of their current operating licenses and to abandon plans for new nuclear power plants. The team strongly suggests utilizing policies that draw on renewable sources for energy efficiency and production, said The Times Leader. The authors also suggest that the U.S. take policy steps to minimize drinking water risks originating from nuclear power.

Meanwhile, following the disaster in Japan, trace amounts of radiation were detected in air and rainwater in several U.S. states including Alaska, Alabama, California, Hawaii, Idaho, Nevada, Pennsylvania, Ohio, Vermont, South Carolina, and Washington. Traces of radioactive iodine-131 also turned up in samples of milk in Spokane, Washington and San Luis Obispo County, California. The EPA also detected the radioactive material iodine-131 in drinking water samples from 13 more U.S. cities.

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Clovis Sues Dow, Shell Oil Over Fouled Water

City takes on companies after farm fumigant found in wells.
By Mark Grossi The Fresno Bee
Friday, Feb. 10, 2012 | 10:22 PM Modified Fri, Feb 10, 2012 10:27 PM

Clovis is suing two chemical manufacturing giants over the toxic remains of a farm fumigant found in drinking-water wells around the community of nearly 100,000 people.

The case will be watched closely by other San Joaquin Valley cities also suing over the same contamination. Clean-water advocates fear this powerful and unregulated chemical, which has been linked to cancer, has been in wells throughout the region for years.

The Clovis case is among at least 11 actions filed against Dow Chemical Co. and Shell Oil Co., seeking the cleanup of 1,2,3-trichloropropane, or TCP. The chemical was in farm fumigants last used in the 1980s. The chemicals were injected into the ground to kill tiny worms called nematodes.

TCP has not yet been regulated because technology does not exist to measure it at extremely low levels, state officials say. The chemical is so toxic that it is unsafe to drink at levels far lower than what can currently be detected — another point of concern for clean-water advocates.

Over the past several years, the chemical has been detected in 18 of Clovis’ 35 active municipal wells, officials say. Cleanup might cost millions of dollars.

The city of Livingston in Merced County last year received $9 million to settle its case against the two manufacturers and a distributor, Wilbur-Ellis Co.

Clovis officials said residents should not have to pay for the cleanup, which would involve the use of carbon filters. A court date for the trial is expected to be set later this year.

Dow disagrees with Clovis and will defend its position, said a spokesman at the company’s Michigan-based headquarters. He declined further comment because the case is in progress.

Shell officials did not respond to a request for comment.

This is not the first time Dow Chemical and Shell Oil have been sued in the Valley over contamination from fumigants. Fresno, Sanger and Livingston won multimillion-dollar settlements from Dow and Shell in the 1990s over the chemical dibromochloropropane, or DBCP.

Wells in many Valley cities already have carbon filters for DBCP. Engineers say filters would have to be larger and changed more often to filter TCP because the contamination level must be reduced much lower than most chemicals in drinking water.

The California Department of Public Health has a goal of keeping TCP to levels in the parts per trillion, which is 1,000 times lower than the limit set for many chemicals.

The TCP health goal, set by state officials in 2009, is .7 parts per trillion, which cannot yet be accurately measured, officials said. An analogy for perspective: One part per trillion is like one penny among $10 billion.

Scientists say TCP causes cancer in laboratory animals and damages the liver and kidneys in humans. Clean-water advocates say state and federal authorities should be moving faster to protect the public.

“TCP is harmful at extremely low levels,” said lawyer Laurel Firestone of the Community Water Center, a nonprofit advocacy group in Visalia. “But it’s not regulated. People don’t know if they’re drinking it or not.”

The Department of Public Health’s website shows TCP has been detected in many San Joaquin Valley cities, including Fresno. Public Works director Patrick Wiemiller said 31 wells in southeast Fresno have been affected. The city has not filed a lawsuit, but legal action has not been ruled out.

Several Kern County cities await their turn in court. They include Bakersfield, Delano, Lamont, Shafter and Wasco. Most of the cases were filed in the past decade. They have been consolidated in San Bernardino Superior Court.

State records show Kern water systems have more than 100 detections of TCP, by far the greatest number in the state.

But the rest of the Valley’s counties also have detections.

Besides Fresno, Kern and Merced, the counties include Tulare, Madera, Kings, Stanislaus and San Joaquin.

http://tinyurl.com/7o27ytm

The reporter can be reached at mgrossi@fresnobee.com or (559) 441-6316.
Similar stories:
Earthlog: Toxin in our water to be revealed
Earthlog: Toxin in our water to be revealed A few weeks ago, the state told me there’s no regulation of a dangerous chemical in the San Joaquin Valley’s drinking water because the chemical can’t be detected at very low levels.
Tainted water flows from taps of rural Valley homes
Tainted water flows from taps of rural Valley homes TOOLEVILLE — From her living room window, Valeriana Alvarado can see the Friant-Kern Canal, where pristine snowmelt flows to farm fields. She wouldn’t mind getting some of that sparkling irrigation water at the drafty two-room trailer where she lives with eight family members. Read more
Pure water turns toxic in nitrate-laced Valley soil
Pure water turns toxic in nitrate-laced Valley soil OROSI — On a crisp winter day, look east from Orosi for a world-class view of the snow-capped Sierra Nevada. The snow melts, rushes down to reservoirs and eventually turns farmlands green. But somewhere between the snowpack and the countryside, a dangerous change takes place.

Read more here: http://www.fresnobee.com/2012/02/10/2718031/clovis-sues-dow-shell-oil-over.html#storylink=cpy

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